Did you know that tuberculosis, caused by the bacteria Mycobacterium tuberculosis is the second highest infectious cause of death worldwide? Being one of the global health challenges, nearly one-quarter of the world’s population is infected with TB bacteria. Though tuberculosis is a curable disease, it becomes difficult to cure when the patient is found to possess drug-resistant tuberculosis. This has raised up the need to improve reliable research in this area prioritizing drug development, diagnosis and vaccine development for tuberculosis.

 scientists of IIT Indore, AIIMS – New Delhi, THSTI- Faridabad, and the University of Bordeaux – France have collaboratively identified 3 significant sites termed as G-quadruplex motifs in the genome of Mycobacterium tuberculosis that can be used as drug targets to destroy the bacteria. The role of the tetrad cluster G-quadruplex was discovered in three genes of Mycobacterium namely cyp51, espK, and espB. Since these genes are responsible for deciding the potential of virulence of bacteria, targeting the three tetrad clusters can substantially prove to be an efficient way to develop tuberculosis drugs. Eventually, the drugs developed could reduce the virulence of bacteria and could terminate the healthy existence of bacteria in human cells.

In today’s scenario, more effective and widely affordable tuberculosis drugs should be found to reinforce the removal of TB in this world. To magnify the impact of basic tuberculosis research, we must encourage such team approaches of researchers. Therefore this discovery made by these group of scientists seems to drive the way for tuberculosis treatment and efficient vaccine identification.

“Fighting against tuberculosis unremittingly is the slogan for this year and depicts our goal for the future” Mao Qun’an


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